Salt-N-Pepa will tell the story of nursing students Cheryl "Salt" James and Sandra "Pepa" Denton, who fell into the world of rap and hip hop, after recording for a friend's school project.

When her husband is hospitalized after a car accident, EMT Karen decides to rent out their spare rooms online. All goes well until Miranda moves in. Miranda quickly infiltrates all areas of Karen's life. When one of Karen's renters is found murdered, Karen becomes convinced Miranda was involved but has no idea that kicking her psychotic guest out will send Miranda into a murderous rage.